Potential for Net Benefit Should Guide Preventive Therapy

An activist's argument that participant values should guide risk–benefit ratio calculations in HIV cure research

The patient empowerment movement, spurred by AIDS activism in the 1980s, quickly evolved to encompass how study participants are considered and treated in clinical research. Initially, people fearing death of AIDS sought early access to experimental medications that had not undergone rigorous testing in hopes of extending their lives. Thirty years on, scientists are asking a different set of et...

Net clinical benefit of warfarin: extending the reach of antithrombotic therapy for atrial fibrillation.

The Net Clinical Benefit of Warfarin : Extending the Reach of Antithrombotic Therapy for Atrial Fibrillation

Should neuroconstructivism guide developmental research?

In her recent paper, Usha Goswami [1] argues in favour of developmental studies of developmental dyslexia, a point that has been well appreciated for at least 20 years [2,3]. She also argues in favour of a certain class of theories of dyslexia, namely theories involving a phonological deficit arising from auditory processing problems, a view that has met with some success [4]. More surprising i...

Opioid dependence and substitution therapy: thymoquinone as potential novel supplement therapy for better outcome for methadone maintenance therapy substitution therapy

Methadone is widely being used for opioid substitution therapy. However, the administration of methadone to opioid dependent individual is frequently accompanied by withdrawal syndrome and chemical dependency develops. Other than that, it is also difficult to retain patients in the treatment programme making their retention rates are decreasing over time. This article is written to higlights th...